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Symbol
Name
ID
Ncstn
nicastrin
MGI:1891700
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
EEG abnormality
Delusion
Schizophrenia
Hallucinations
Negativism
Social and occupational deterioration
Disease(s) Associated with NCSTN
schizophrenia

Mouse Phenotypes
nervous system phenotype
increased neuron apoptosis
increased embryonic neuroepithelium apoptosis
abnormal neural tube morphology
abnormal neural crest morphology
kinked neural tube
loss of cortex neurons
thin cerebral cortex
astrocytosis
gliosis
decreased CNS synapse formation
decreased myelin sheath thickness
abnormal dendrite morphology
dysmyelination
decreased prepulse inhibition
Availability Mouse Genotype
Ncstntm1Pcw/Ncstntm1Pcw
Ncstntm1Rroz/Ncstntm1Rroz
Ncstntm1.1Sud/Ncstntm1.1Sud
Tg(Camk2a-cre)1Shn/0  (conditional)
*
Ncstntm1.1Sud/Ncstntm1.1Sud
Olig1tm1(cre)Rth/Olig1+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory